Glucose-6-Phosphate Dehydrogenase(G6PD) deficiency

Is the most common human enzyme deficiency; an estimated 400 million people worldwide are affected by this enzymopathy (Scriver etal., 1995). One benefit of having G6PD deficiency is that it confers a resistance to malaria. G6PD deficiency is also sometimes referred to as favism since some G6PD deficient individuals are also allergic to fava beans.

Individuals with reduced G6PD activity are at risk for several pathologies which can be potentially serious (even causing death) if they are not properly treated.The severity of the pathologies associated with G6PD deficiency has prompted researchers to study this condition. Since the discovery of G6PD deficiency in 1956, thousands of research papers have been published on various aspects of this genetic condition (Carson et al., 1956; Beutler, 1994). It is therefore important to learn about G6PD deficiency; more specifically, this WEB site will introduce the genetic, physiological, molecular, and clinical aspects of this condition.

Dr. Ernest Beutler, who first identified the G6PD enzyme deficiency in 1953, was a giant among scientists and a most generous, gracious person.

Glucose-6-phosphate dehydrogenase (G6PD) is a cytosolic enzyme in the pentose phosphate pathway, a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage. Of greater quantitative importance is the production of NADPH for tissues actively engaged in biosynthesis of fatty acids and/or isoprenoids, such as the liver, mammary glands, adipose tissue, and the adrenal glands.

It is notable in humans when there is a genetic deficiency which predisposes to non-immune haemolytic anaemia.

DRUGS incompatible with the FAILURE of the enzyme G-6-PD
Active Substance Therapeutic Category TRADEMARK
2-amino-5 sylphanyltheiazole Sulphamides
Acetanylide Analgesic Antifebrin
Acetophenetidine Analgesic Phenacetin
Acetophenetidine Analgesic Treupel
Acetylphenylhydrazine Antimicrobial
AcetylSalycilic Acid Analgesic Aspirin
AcetylSalycilic Acid Analgesic Neospir
Aminopyrine Analgesic Pyramidon
Amyl nitrite Antidote
Antipyrine Analgesic Lonarid
Antipyrine Analgesic Phenazol
Ascorbic Acid - Vitamin C
Astemizole Antihistaminic
Azatadine Antihistaminic
Benzehol Artane
Brompheniramine Antihistaminic
Captopril Anti-Hypertention Capoten
Celecoxib Antiinflammatory
Cetirizine Antihistaminic
Chloramphenicol Antimicrobial Chloromycetin
Chloroguanidine Paludrine
Chloroquine Antimalarial Chloroquine
Chlorpheniramine Antihistaminic
Cinoxacin Quinolones Cinobac
Ciprofloxacin Quinolones Ciproxin
Cyproheptadine Antihistaminic
Dantrolene sodium Hyperpyrexia Dantrolene
Demerkaptole BAL
Dephenylydramine Benedryl
Desferioxamine Desferal
Dexchlorpheniramine Antihistaminic
Diamino-diphenylosulphone Sulphones DDS
Dimentindene Antihistaminic
Diphenhydramine Antihistaminic
Doxorubicin Antineoplastic Adriblastina
Ebastine Antihistaminic
Enalapril maleate Anti-Hypertention Renitec
Fluothane Anesthetic
Furaltadone Nitrofurans Altafur
Furazolidone Nitrofurans Furoxon
Glibenclamide Anti-diabetic Daonil
Hydroxyzine Antihistaminic
Isoniazide Antibacterial Rifamate
Isoniazide Antibacterial Myambutol INH
Isoniazide Antibacterial Dianicotyl
Kinoside Quinosid
L-Dopa Anti-epileptic Sinemet
L-Dopa Anti-epileptic Larodopa
Loratadine Antihistaminic
Menaphthone Prothrombogenic
Mequitazine Antihistaminic
Methylene blue
Nalidixic Acid Quinolones Wintomylon
Nifuroxaside Nitrofurans Ercefuril
Nitrofurantoin Nitrofurans Furadantin
Nitrofurazone Nitrofurans Furacin
Norfloxacin Quinolones Norocin
Nyridazole Ambilhar
Ofloxacin Antihistaminic
Pamaquine Plasmaquine
Para-amino benzoic acid PABA
Paracetamol Analgesic Depon
Paracetamol Analgesic Panadol
Paracetamol Analgesic Paracetamol
Paraminosalycilic Acid Analgesic PAS
Pentaquine Antimalarial Pentaquin
Phenylbutazone Antiinflammatory Tanderil
Phenylhydrazine Hemolytic
Phenytoin Antiepileptic Epanutin
Phenytoin Antiepileptic Dilantin
Phytomenadione Prothrombogenic Koniakin
Primaquine Antimalarial Primaquin
Procainamide HCl Antiarrythmic Pronestyl
Promethazine Benemid
Pyrinethamine Daraprin
Quinacrine Antimalarial Atabrin
Quinidine Antimalarial Quinidicardine
Quinine Antimalarial Quinine
Salisylazosulphanylamide Antibacterial Azulfidine
Sodium nitrite Antidote
Streptomycin Antimicrobial Streptomycin
Sulfacetamide Antibacterial Sultrin
Sulfisoxazole Antibacterial Gantrisin
Sulphacetamide Antibacterial Sulphachlor
Sulphacetamide Antibacterial Sulfanicol
Sulphacetamide Antibacterial Sulfachloramphenicol
Sulphacitin Antibacterial Erythrom/Sulfisox
Sulphadiazine Antibacterial
Sulphamethoxazole Antibacterial Septrin
Sulphamethoxazole Antibacterial Sulfamethoxazole
Sulphamethoxazole Antibacterial Bactrimel
Sulphamethoxazole Antibacterial Gantanol
Sulphamethoxypyridazine Antibacterial Leder Kyn
Sulphamethoxypyridazine Antibacterial Folisulfe
Sulphamethoxypyridazine Antibacterial Sulfexin
Sulphanilamide Antibacterial AVC
Sulphapyridine Antibacterial
Sulphazoguanidin Antibacterial
Sulphisoxazole Antibacterial Gantrisin
Sulphosone Antibacterial Diasone
Terfenadine Antihistaminic
Theiazosulphone Antibacterial Promizole
Tolouidine Blue
Toluene Hydrochloride
Tribenzamine Pyribenzamine
Trimethoprim Antibacterial Trimethoprim
Trinitrotoluene TNT
Trinitrotoluene Trinitrine
Uric Acid
Vitamin K

OTHER SUBSTANCES incompatible with the FAILURE of the enzyme G-6-PD
Beverages containing quinine Tonic water
Lawsomia mermis (Henna) cosmetic
Fava beans food

This table was prepared with the assistance of Dr. Cleopatra Soulpi, Director of the Department of Preventive Control, of the Institute of Child Health. Last updated: December 2008