The prognistic value of visual evoked response latency in the treatment of amblyopia caused by strabismus
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Documenta Ophthalmologica 92: 223--228, 1996.
Q 1996 Kluwer Academic Publishers. Printed in the Netherlands.

The prognostic value of visual evoked response latency in the treatment of amblyopia caused by strabismus

EVANGELOS ILIAKIS, MICHAEL MOSCHOS, NIKOLAOS HONTOS,


JOHN KOTSIRAS MARIA TSALOUKI & ELEPHTHERIA CHIMONIDOU
Department of Strabismus and Laboratory of Electrophysiology, University Eye Clinic of
Athens, Greece

Accepted 7 November 1995

Key words: Amblopia ex anopsia, PI00 latency, Strabismus, Visual evoked responses.

Abstract.
Visual evoked response alterations and especially PI00 latency were studied in 60
patents with amblyopia caused by strabismus. Patients were divided in two groups according to the mode of fixation
of the strabismic eye. Group A included patients with eccentric fixation, and group B, patients with central
fixation of the strabismic eye. In all cases visual evoked responses were recorded before and after a 6-month
period during which the patients had full-time occlusion of the sound eye. In cases with eccentric fixation of
the strabismic eye, P100 latency was more abnormal than in cases with central fixation. In cases where latencies
are clearly abnormal before treatment, the prognosis is poor and the results after occlusion of the sound eye are
unstable. In contrast, in the cases with normal or nearly normal visual evoked response latencies, the prognosis is
better, and these eyes show satisfactory improvement of visual acuity.

Introduction
Amblyopia may be considered a sequel of suppression in cases where strabismus is not alternated. In these cases there
is no real lesion of the optic tract but an inhibition of the deviated eye caused by suppression or disuse of the fovea.
Nevertheless, many studies [1-7] have addressed the visual evoked response (VER) changes in amblyopia and their prognostic
value in its treatment [8-10]. We studied the changes of P100 latency of the VER in a number of patients with amblyopia
caused by strabismus and evaluated their
prognostic value.

Patients and methods
Sixty patients aged 6 to 9 years with amblyopia caused by strabismus were
studied in the Laboratory of Electrophysiology at the University Eye Clinic
of Athens, Greece.

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